About Hologic

Hologic, Inc. (Nasdaq: HOLX) is a leading developer, manufacturer and supplier of premium diagnostic products, medical imaging systems, and surgical products dedicated to serving the healthcare needs of women throughout the world.

At Hologic, we are on a mission: to help women everywhere lead longer, healthier lives. It is our reason for being and the single focus of every breakthrough we pursue, every solution we design, every investment we make.

Hologic is the leader in ten areas of women's health that matter most including mammography and breast biopsy; radiation treatment for early-stage breast cancer; breast MRI, cervical cancer screening; treatment for menorrhagia; permanent contraception; osteoporosis assessment; preterm birth risk assessment; mini C-arms for extremity imaging; as well as molecular diagnostic products, including human papillomavirus (HPV) testing and reagents for a variety of DNA analysis applications. We offer clinicians the tools they need to spot cancer or osteoporosis while they can still do something about it. And treat the whole woman at every stage of her life, not just the disease.

We are proud of this achievement and conscious of the responsibility that our leadership position brings with it. We believe that the health issues facing women today deserve and demand the singular dedication of a passionate company.

Our core business units are focused on breast health, diagnostics, GYN surgical, and skeletal health.

Breast Health

"You have cancer. Fortunately, we caught it early."

At Hologic, our focus and concentration on breast cancer is unmatched. No other major healthcare company devotes a higher percentage of its resources to the development and deployment of screening, diagnostic and therapeutic technologies to meet the challenges of this disease.

It's one reason why so many radiologists, surgeons, and radiation oncologists rely on Hologic solutions for digital mammography, breast biopsy, and accelerated partial breast irradiation.

Our Selenia® digital mammography systems and SecurView® diagnostic workstations are leading the industry in the transition from analog to a digital environment. More than a single technology, Selenia digital mammography represents an integrated suite of technical advances, pushing the science of breast cancer detection forward. We understand the constantly changing digital environment and the need for a flexible, compatible computer-aided detection solution. Our ImageChecker® CAD delivers proven performance and has been the leading CAD technology for more than a decade. For added comfort, our MammoPad® breast cushion offers a softer, warmer mammogram to help lower the patients' anxiety allowing the technologist to obtain more of the chest wall in the image and ensure even compression of the breast.

If a suspicious lesion is detected, we support the next clinical steps: our ATEC®, Eviva® and Celero® breast biopsy systems, coupled with our MultiCare® Platinum prone biopsy table and StereoLoc® II upright biopsy platform, provide clinicians with easier and more effective access to lesions with fewer needle insertions.

Should cancer be detected in its early stages, many women are candidates for the Hologic MammoSite® radiation therapy system, a unique and welcomed clinical option, and a patient-friendly alternative to traditional whole breast radiation. MammoSite is the most widely utilized and accepted method of accelerated partial breast irradiation in the United States. With its multi-lumen design, our new MammoSite ML device gives radiation oncologists the ability to shape the radiation dose for typical cases and treat patients who are otherwise not appropriate candidates for traditional brachytherapy.

Our ground breaking Sentinelle Medical® Vanguard™ system allows healthcare providers to take advantage of unique technologies not available in traditional tabletop coils. Our Sentinelle Breast MR Auxiliary Table provides complete and open access for intervention, and award winning design for optimal patient comfort and workflow. And our Aegis™ imaging and interventional computer software aids in the guidance of biopsy procedures and allows the radiologist to view and manipulate the MR images in three dimensions.

Throughout the developed worlds, our breast cancer screening solutions and interventional therapies are the preferred choice for large numbers of physicians, administrators and technologists. As an extension of our global commitment to women's healthcare, we support humanitarian programs with contributions of imaging, screening, diagnostic, and therapeutic equipment to a variety of countries, including Macedonia, Tanzania, Nicaragua, Thailand, and South Africa. Through these important initiatives, many women are receiving preventative screening exams for the first time in their lives.

Diagnostics

We believe that women deserve a better answer

We take great pride in the screening and diagnostic capabilities that we have developed for physicians focused on prenatal and gynecological health.

The most widely known is the ThinPrep® Pap test and Imaging system. For women, it means confidence: ThinPrep technology has set new standards for cervical cancer screening that both women and the medical community have come to rely on. With the ThinPrep Pap test, there are much higher detection levels for precancerous cells, giving physicians and patients more time to undertake appropriate treatment.

A pregnant woman has special concerns: her baby's health, her own health. Our fFN™ fetal fibronectin test gives OBGYNs a clear picture of preterm birth probabilities - valuable information to support treatment options for the mother if necessary. We offer a second important test for women during pregnancy called InPlex® CF: a molecular test that can identify genetic mutations associated with cystic fibrosis in both the mother and the unborn child.

HPV is the most common sexually transmitted disease in the United States and is recognized as the cause of most cervical cancers. To help prevent the onset of disease, the American College of Obstetrics and Gynecology suggests routine Pap and HPV testing for women over the age of 30 to identify women most likely to develop cervical cancer.

Cervista HPV HR, designed to detect the 14 high-risk types of human papillomavirus (HPV) known to cause cervical cancer, is the first HPV DNA test approved by the FDA in more than 10 years. Cervista HPV 16/18 is the first HPV test approved for genotyping for HPV types 16 and 18, known to be associated with approximately 70 percent of all cervical cancers in the United States. Both of these HPV tests complement our ThinPrep Pap test platform for early detection of cervical cancer.

Our Cellient™ automated cell block system is the first commercially available fully automated system that allows individual cells or small tissue samples to be processed for histological examination. The vacuum-assisted filtration concentrates available cells within the block. The result is diagnostically useful, high-quality blocks that are created in less than an hour and can be reviewed efficiently.

Surgical Health

We continue to support a woman's gynecological health past her child-bearing years. NovaSure® endometrial ablation is the market-leading technology and preferred clinical procedure for treating the condition of menorrhagia. Thanks to the NovaSure system, nearly one million women have been able to dramatically improve the quality of their lives, freed from the debilitating impact of excessive menstrual bleeding.

Our Adiana® permanent contraception system is a safe and simple hysteroscopic procedure that provides women with permanent contraception. The Adiana procedure is minimally invasive, requires no incisions, and using local anesthesia, can be performed in the comfort of the doctor's office.

Skeletal Health

In the U.S. roughly four out of ten white women over age 50 will experience a hip, spine, or wrist fracture sometime during the remainder of their lives. Looking ahead, the lifetime risk of fractures will increase for all ethnic groups as people live longer. Early detection and treatment can mean a lifetime of health and vitality for women.

Osteoporosis is often a silent thief - when she least expects it; osteoporosis robs a woman of her vitality, her confidence, her spirit. Helping women fight this disease requires especially sensitive care from their physicians - supported by early detection and appropriate treatment to rebuild strong and healthy bones.

Our work in the detection of osteoporosis is one more example of our special commitment to addressing those health challenges that threaten women most severely.

We pioneered dual x-ray bone densitometry technology, which has become the industry standard for assessing bone health. Using our Discovery™ system, clinicians can identify fractures not discernible by normal examinations. An added benefit of these advances is the growing use of the same technologies to measure body composition and support the diagnosis of heart disease. Today there is no definitive cure for osteoporosis. But we will continue to make state-of-the art detection and diagnosis solutions until medical science can develop an answer.

Emerging Technologies

One area that is receiving a great deal of attention in both Hologic and the medical press is our work on breast tomosynthesis. Tomosynthesis makes it possible to obtain three-dimensional images of the breast and to view one slice at a time by removing the images of the overlying and underlying tissues that confuse an ordinary breast x-ray. The greater clarity of the resulting image is expected to lead to the achievement of important clinical benefits, such as increasing the breast cancer detection rate and decreasing the number of false positives that result in unnecessary and emotionally stressful call backs for additional examinations. Hologic's breast tomosynthesis imaging technology, Selenia® Dimensions®, is available commercially in more than a dozen countries, including countries in Europe, the Middle East, South America, Asia and Australia. In North America, commercial Selenia Dimensions systems are installed in Canada and Mexico. In the United States, Selenia Dimensions is currently available as a two dimensional (2-D) only system that is upgradeable to do breast tomosynthesis (3-D) imaging when and if the product is approved by the FDA.

Each year, we spend millions of dollars on research and development to deliver more advanced and innovative imaging, intervention, and treatment solutions to save even more lives. Our research is focused on pushing the boundaries of science and technology to accelerate the screening and detection of disease, identify less invasive therapies, and uncover technological breakthroughs in diagnostics and therapeutics. The results of our relentless explorations are evident in the products we create, the screening programs we enable, and the improvements in patient outcomes our technologies help make possible.

We know of no other major healthcare company that devotes a higher percentage of its resources to the development and deployment of screening, diagnostic, and therapeutic technologies designed to help doctors see better, know sooner, and reach further.

This is our commitment to the women of the world.

Worldwide Operations

With centers of operation in North America, Europe, Central America, Australia, and Asia, Hologic is focused on extending its medical systems and solutions to benefit women around the world. We have the strength and resources of a billion dollar company and the vision of leaders committed to a broad spectrum of women's health issues. Our 4,000 employees are driven toward breakthrough achievements in research, product development, and the worldwide distribution of healthcare solutions.

And we have the unwavering partnerships of thousands of healthcare professionals who match our dedication to extending and enriching the lives of women everywhere. As a result, our screening solutions and interventional therapies are the preferred choice for large numbers of physicians, administrators, and technologists throughout the developed world.

Together we cannot fail.