Breast Cancer Diagnosis

Staging

Staging is the process used to determine the extent a cancer has spread beyond the primary site. The stage of a cancer is one of the most important factors to be considered when planning a treatment program.

The staging system most commonly used to provide a standardized method of describing the extent to which a breast cancer has spread is the Staging System of the American Joint Committee on Cancer. This system is sometimes referred to as the TNM system because it evaluates three components to determine the stage of a cancer:

  • T = tumor size and spread to the skin or chest wall under the breast. The extent of the tumor is expressed in a numerical value from 0 to 4, with higher T numbers indicating a larger tumor or more extensive spread to the skin or chest wall;


  • N = the extent to which the cancer has spread to lymph nodes near the breast and the degree to which the affected nodes are fixed (stuck) to other structures under the arm. The extent of spread is expressed in a numerical value from 0 to 3, with the higher number denoting more extensive spread;


  • M = the extent to which the cancer has metastasized to distant organs or to lymph nodes that are not next to the breast. The extent of metastasis is shown in a numerical value from 0 to 1, with 1 indicating the most extensive spread.

The following is a summary of breast cancer T, N, and M Categories and Stage Groupings:

Primary Tumor (T)
TX Cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ
T1 Tumor 2 cm. or less in greatest dimension
T2 Tumor more than 5 cm.
T3 Tumor more than 5 cm.
T4 Tumor of any size with direct extension to skin or chest wall
Regional Lymph Nodes (N)
NX Cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis to mobile ipsilateral (same side as the breast cancer) lymph node
N2 Metastasis to ipsilateral nodes that are fixed to one another or other structures
N3 Metastasis to ipsilateral internal mammary lymph nodes (located beneath the breast and inside the chest)
Distant Metastasis (M)
MX Cannot be assessed
M0 No distant metastasis
M1 Distant metastasis is present

The final step in determining a woman's disease state is a process called stage grouping, in which the stage is expressed in Roman numerals from Stage 0 (least advanced) to Stage IV (most advanced).

The following table summarizes Breast Cancer Stage Grouping:

Breast Cancer Stage Grouping
  T (Tumor) N (Nodes) M (Metastasis)
Stage 0
Tis
N0
M0
Stage 1
T1
N0
M0
Stage IIA
T0
N1
M0
 
T1
N1
M0
 
T2
N0
M0
Stage IIB
T2
N1
M0
 
T3
N0
M0
Stage IIIA
T0
N2
M0
 
T1
N2
M0
 
T3
N1, N2
M0
Stage IIIB
T4
Any N
M0
 
Any T
N3
M0
Stage IV
Any T
Any N
M1

 

This website provides general information only.
A physician should be contacted if you need any medical advice
or if medical decisions need to be made.


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