Staging
Staging is the process used to determine the extent a cancer
has spread beyond the primary site. The stage of a cancer is one of
the most important factors to be considered when planning a treatment
program.
The staging system most commonly used to provide a standardized
method of describing the extent to which a breast cancer has spread
is the Staging System of the American Joint Committee on Cancer. This
system is sometimes referred to as the TNM system because it evaluates
three components to determine the stage of a cancer:
- T = tumor
size and spread to the skin or chest wall under the breast. The
extent of the tumor is expressed in a numerical value from 0
to 4, with higher T numbers indicating a larger tumor or more
extensive spread to the skin or chest wall;
- N = the extent
to which the cancer has spread to lymph nodes near the breast
and the degree to which the affected nodes are fixed (stuck)
to other structures under the arm. The extent of spread is expressed
in a numerical value from 0 to 3, with the higher number denoting
more extensive spread;
- M = the extent
to which the cancer has metastasized to distant organs or to
lymph nodes that are not next to the breast. The extent of metastasis
is shown in a numerical value from 0 to 1, with 1 indicating
the most extensive spread.
The following is a summary of breast cancer T, N, and M
Categories and Stage Groupings:
| Primary Tumor (T) |
| TX |
Cannot be assessed |
| T0 |
No evidence of primary tumor |
| Tis |
Carcinoma in situ |
| T1 |
Tumor 2 cm. or less in greatest dimension |
| T2 |
Tumor more than 5 cm. |
| T3 |
Tumor more than 5 cm. |
| T4 |
Tumor of any size with direct extension to skin or chest wall |
| Regional Lymph Nodes (N) |
| NX |
Cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Metastasis to mobile ipsilateral (same side as the breast cancer) lymph node |
| N2 |
Metastasis to ipsilateral nodes that are fixed to one another or other structures |
| N3 |
Metastasis to ipsilateral internal mammary lymph nodes (located beneath the breast and inside the chest) |
| Distant Metastasis (M) |
| MX |
Cannot be assessed |
| M0 |
No distant metastasis |
| M1 |
Distant metastasis is present |
The final step in determining a woman's disease state is
a process called stage grouping, in which the stage is expressed in
Roman numerals from Stage 0 (least advanced) to Stage IV (most advanced).
The following table summarizes Breast Cancer Stage Grouping:
| Breast Cancer Stage Grouping |
| |
T (Tumor) |
N (Nodes) |
M (Metastasis) |
| Stage 0 |
Tis |
N0 |
M0 |
| Stage 1 |
T1 |
N0 |
M0 |
| Stage IIA |
T0 |
N1 |
M0 |
| |
T1 |
N1 |
M0 |
| |
T2 |
N0 |
M0 |
| Stage IIB |
T2 |
N1 |
M0 |
| |
T3 |
N0 |
M0 |
| Stage IIIA |
T0 |
N2 |
M0 |
| |
T1 |
N2 |
M0 |
| |
T3 |
N1, N2 |
M0 |
| Stage IIIB |
T4 |
Any N |
M0 |
| |
Any T |
N3 |
M0 |
| Stage IV |
Any T |
Any N |
M1 |
|