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Actim® PROM

Hologic is now the exclusive U.S. distributor of Actim PROM – A rapid test for detection of PROM that’s effective even in the presence of vaginal bleeding.*

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    Overview

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    Overview

    Premature Rupture of Membranes (PROM) is One of the Leading Causes of Preterm Birth.1

    Amniotic fluid is not typically found in the vagina, but when membranes rupture, amniotic fluid leaks into the vagina and insulin-like growth factor binding protein-1 (IGFBP-1) concentration rises quickly. 

    Symptoms of PROM differ between patients, so diagnosing this condition can often be challenging and time consuming.

    Illustration of baby in womb with data points.

    Actim PROM – A Unique Test That Detects IGFBP-1 in Vaginal Fluids.2

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    IGFBP-1 concentrations in amniotic fluid rise early during pregnancy and remain elevated until birth. Actim PROM is based on highly specific and unique monoclonal antibodies that bind to IGFBP-1. 

    Thanks to its optimal cut-offs, Actim PROM can identify even the smallest of ruptures with minimal risk of false positives due to the very low levels of IGFBP-1 normally found in the vagina during pregnancy.

    A Rapid Diagnostic Test for the
    Detection of PROM.2

    Actim PROM is a visually interpreted, qualitative immunoassay rapid test for the detection of amniotic fluid in cervicovaginal secretions during pregnancy. 

    Ordering Information

    Actim PROM 10 Test Kit

    Actim PROM Control Test Kit 

    Part Number

    30831ETUS

    30800ETUS

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    A Rapid Diagnostic Test for the Detection of PROM.2

    Actim PROM results available in 5 minutes.

    Specimens for testing can be collected with or without a speculum.

    Actim PROM remains effective in the presence of some vaginal bleeding, a condition present in up to 20% of PROM patients.3

    Accurate PROM diagnosis helps enable proper patient care while avoiding unnecessary treatment and reducing costs.

    Hologic is now the exclusive distributor for Actim PROM in the United States.

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    *The test has been designed to minimize interference from bleeding, but in cases of heavy bleeding the blood locally may have a higher concentration of IGFBP-1 protein. In these cases, a positive result should be interpreted with caution.
    Hologic and associated logos are trademarks and/or registered trademarks of Hologic, Inc. and/or its subsidiaries in the United States and/or other countries. Certain images, text, and related content displayed on this webpage is used with the permission of Actim Oy. 
    Actim® is a registered trademark of Actim Oy. 
    All other trademarks that may appear are the property of their respective owners.
      References
      1. Jazayeri A. Premature Rupture of Membranes. Medscape. Last reviewed February 24, 2023. Accessed May 5, 2025. https://emedicine.medscape.com/article/261137-overview#a1 2. Actim PROM Test Kit Instructions For Use. A30831ETUS-IFU Rev. C. Hologic, Inc.; 2025. 3. Palacio et al.Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes. BMC Pregnancy and Childbirth. 2014;14:183. doi: 10.1186/1471-2393-14-183
      Documents

      Safety Data Sheet from Manufacturer

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